Sam Okuayinonu
NFL Injury Report

Sam Okuayinonu Injury Status

San Francisco 49ers • DT
Latest Injury Status
Injured Reserve
IR

Okuayinonu was already ruled out for Week 1 against the Rams due to a foot injury, which is severe enough for him to go on injured reserve. That means he'll be required to miss at least four games (barring an injury settlement), so the earliest Okuayinonu can return is Week 5 against the Seahawks on Sunday, Oct. 11. In a corresponding move, the 49ers signed edge rusher Khalid Kareem from the Falcons' practice squad to the active roster.

Injury Details

Body Part
Foot
Location
Leg
Side
Not Specified
Expected Return
Oct 11, 2026

Betting Research

Player availability can affect minutes, usage, matchup assignments, team totals and player-prop markets. Compare the latest injury information with current prices before making a betting decision.

Sam Okuayinonu Injury History

September 7, 2026
Injured Reserve • Foot
Not Specified
The 49ers placed Okuayinonu (foot) on injured reserve Friday.
September 5, 2026
Injured Reserve • Foot
Not Specified
ir
September 5, 2026
questionable • Foot
Not Specified
questionable
September 4, 2026
out • Foot
Not Specified
Okuayinonu (foot) will not travel with the team to Melbourne, Australia ahead of the Week 1 game versus the Rams, Nick Wagoner of ESPN.com reports.
September 4, 2026
out • Foot
Not Specified
out
September 4, 2026
questionable • Foot
Not Specified
questionable
August 31, 2026
active
Okuayinonu recorded two solo tackles in Thursday night's 41-17 preseason win over the Chargers.
August 22, 2026
active
August 21, 2026
questionable • Ankle
Not Specified
questionable

Latest Sam Okuayinonu Injury Updates

This page tracks available injury information for Sam Okuayinonu, including reported status, injury details, expected return information and updates that may be relevant when evaluating NFL betting markets.

Injury designations can change close to game time. Check the latest market prices and confirmed player availability before placing a wager.